Anesthesia Residents' Vital Information Navigator
A collection of some of the most common calculations; and some uncommonly done procedures in Anesthesiology
Eleveld TCI Model
| State | BIS Range |
|---|---|
| Awake | 98 - 100 |
| Minimal sedation | 78 - 85 |
| Moderate sedation | 70 - 78 |
| Deep sedation | 60 - 70 |
| General anesthesia | 45 - 60 |
| Over medicated | < 45 |
Glasgow Coma Score
ACLS Cardiac Arrest Algorithm
Shockable Rhythm (VF / pVT)
- Defibrillate: Biphasic 120-200J (or manufacturer recommendation)
- CPR 2 minutes. IV/IO access
- Defibrillate again if still shockable
- Epinephrine 1 mg IV/IO every 3-5 minutes
- Defibrillate
- Amiodarone 300 mg IV/IO bolus (2nd dose: 150 mg)
- Continue CPR cycles. Consider reversible causes
Non-Shockable (Asystole / PEA)
- CPR 2 minutes. IV/IO access
- Epinephrine 1 mg IV/IO every 3-5 minutes
- CPR 2 minutes. Check rhythm every 2 min
- Identify and treat reversible causes (H's and T's)
H's
- Hypovolemia
- Hypoxia
- Hydrogen ion (acidosis)
- Hypo/Hyperkalemia
- Hypothermia
T's
- Tension pneumothorax
- Tamponade (cardiac)
- Toxins
- Thrombosis (PE)
- Thrombosis (coronary)
CPR / Epinephrine Timer
Difficult Airway Algorithm
Based on ASA Practice Guidelines for Management of the Difficult Airway
Mallampati, thyromental distance, neck mobility, mouth opening, obesity, history
Awake intubation vs. intubation after induction of general anesthesia
Topicalize airway. Flexible bronchoscopy or video laryngoscopy. Confirm with ETCO2.
Attempt direct/video laryngoscopy. Use bougie, different blade, external laryngeal manipulation.
Place LMA/iGel. If ventilation adequate, consider: wake patient, intubate via SGA, or proceed with SGA.
Cannot Intubate, Cannot Oxygenate
Front-of-neck access (cricothyrotomy)
Scalpel-bougie-tube technique
LAST - Local Anesthetic Systemic Toxicity
Recognition
| Stage | Symptoms |
|---|---|
| CNS (early) | Tinnitus, metallic taste, perioral numbness, agitation, dizziness |
| CNS (late) | Seizures, loss of consciousness |
| Cardiovascular | Hypotension, bradycardia, arrhythmias, cardiac arrest |
Management
- Stop injection of local anesthetic immediately
- Call for help. Get Intralipid 20%
- Airway management - 100% O2, avoid hyperventilation
- Seizure suppression: Midazolam (preferred) or small dose Propofol. Avoid large doses of propofol
- If cardiac arrest: Start CPR. Avoid vasopressin, calcium channel blockers, beta blockers, local anesthetics (lidocaine)
Intralipid 20% Protocol
- Bolus: 1.5 mL/kg over 1 minute
- Infusion: 0.25 mL/kg/min
- Repeat bolus 1-2 times if cardiovascular instability persists
- Increase infusion to 0.5 mL/kg/min if needed
- Maximum total dose: 12 mL/kg
For 70 kg patient: Bolus = 105 mL, Infusion = 17.5 mL/min (1050 mL/hr)
Malignant Hyperthermia
Recognition - Early Signs
| Sign | Details |
|---|---|
| Unexplained rise in ETCO2 | Most sensitive and earliest sign. Unresponsive to increased ventilation |
| Masseter muscle rigidity | After succinylcholine administration |
| Tachycardia | Unexplained, often sinus tachycardia or ventricular arrhythmias |
| Tachypnea | In spontaneously breathing patients |
| Hyperthermia | Late sign - temperature rises 1-2°C every 5 min. May exceed 43°C |
| Metabolic acidosis | Mixed respiratory and metabolic acidosis |
| Muscle rigidity | Generalized (not always present) |
| Rhabdomyolysis | Elevated CK, myoglobinuria (dark/cola-colored urine) |
Triggering Agents
Triggers (AVOID)
- Succinylcholine
- All volatile anesthetics:
- Sevoflurane
- Desflurane
- Isoflurane
- Halothane
Safe Agents
- Propofol
- Opioids (all)
- Benzodiazepines
- Ketamine
- Etomidate
- Nitrous oxide
- Non-depolarizing NMBAs
- Local anesthetics
- Dexmedetomidine
Immediate Management
- STOP all triggering agents immediately. Turn off vaporizer. Do NOT delay for machine change.
- Hyperventilate with 100% O2 at high fresh gas flows (≥ 10 L/min)
- Dantrolene 2.5 mg/kg IV bolus. Repeat every 5 min as needed. No max dose in acute crisis.
- Call for help. Assign roles. Get MH cart.
- Notify surgeon - conclude surgery ASAP if possible
Dantrolene Dosing
Preparation: Each vial = 20 mg lyophilized powder. Reconstitute with 60 mL sterile water. For 175 mg = 9 vials.
Ryanodex: 250 mg/vial, reconstitute with 5 mL sterile water. Much faster to prepare.
Supportive Measures
| Problem | Treatment |
|---|---|
| Hyperthermia | Active cooling: cold IV NS, ice packs (axillae, groin, neck), cooling blanket, cold lavage. Target <38.5°C then stop active cooling. |
| Hyperkalemia | Calcium chloride 10 mg/kg or calcium gluconate 30 mg/kg. Insulin 0.1 U/kg + glucose 0.5 g/kg. Sodium bicarbonate 1-2 mEq/kg. Hyperventilate. |
| Metabolic acidosis | NaHCO3 1-2 mEq/kg IV guided by ABG |
| Arrhythmias | Treat hyperkalemia first. Amiodarone for persistent arrhythmias. AVOID calcium channel blockers with dantrolene (cardiac arrest risk) |
| Myoglobinuria | IV fluids to maintain UO >2 mL/kg/hr. Consider mannitol (within dantrolene) or furosemide. |
| DIC | Check coagulation studies. Treat with FFP, cryoprecipitate, platelets as needed. |
Monitoring / Labs
- ABG, electrolytes (K+, Ca2+), lactate q15-30 min
- CK (peaks at 12-24 hrs, may exceed 20,000)
- Urine output, myoglobin
- Coagulation studies (PT, PTT, fibrinogen, D-dimer)
- Core temperature (esophageal or bladder preferred)
Post-Crisis Management
- Dantrolene 1 mg/kg IV q4-6h for at least 24 hours (recrudescence occurs in ~25%)
- ICU admission for at least 24-72 hours
- Monitor CK, renal function, potassium, coagulation q6h
- Maintain UO >2 mL/kg/hr
- Refer patient and family for caffeine-halothane contracture testing (CHCT) and genetic testing (RYR1 mutation)
- Report to MHAUS (Malignant Hyperthermia Association of the United States)
Dexmedetomidine IV Drip
Stock Preparation: 200 mcg/1 mL
| Dose (mcg/kg/hr) | Regulation (mL/hr) | Dose (mcg/kg/hr) | Regulation (mL/hr) |
|---|
Ketamine IV Drip
Stock Preparation: 500 mg/10 mL (50 mg/mL)
| Dose (mg/kg/hr) | Regulation (mL/hr) |
|---|
Propofol
Stock: 10 mg/mL (200 mg/20 mL). No dilution needed.
| Dose (mcg/kg/min) | mL/hr |
|---|
Remifentanil IV Drip
Stock: 1 mg vial
| Dose (mcg/kg/min) | Regulation (mL/hr) |
|---|
Dopamine IV Drip
Stock: 250 mg/5 mL. Max Dose: 40 mcg/kg/min
| Dose (mcg/kg/min) | mL/hr | Dose (mcg/kg/min) | mL/hr |
|---|
Dobutamine IV Drip
Stock: 250 mg/20 mL. Dose range: 2-20 mcg/kg/min
| Dose (mcg/kg/min) | mL/hr |
|---|
Epinephrine IV Drip
Stock: 1 mg/mL (1:1000)
| Dose (mcg/kg/min) | mL/hr |
|---|
Amiodarone
Mix: 900 mg in 500 mL D5W (1.8 mg/mL)
Loading
| Phase | Dose | Rate | Duration |
|---|---|---|---|
| Rapid Loading | 150 mg | 15 mg/min | 10 min |
| Slow Loading | 360 mg | 1 mg/min | 6 hours |
| Maintenance | 540 mg | 0.5 mg/min | 18 hours |
Lidocaine 2% Drip for Arrhythmia
Stock: Lidocaine 2% (20 mg/mL). Mix: 2 g in 500 mL (4 mg/mL). Loading: 1-1.5 mg/kg bolus
| Rate (mg/min) | mL/hr |
|---|---|
| 1 | 15 |
| 2 | 30 |
| 3 | 45 |
| 4 | 60 |
Labetalol
IV Bolus
| Method | Dose | Details |
|---|---|---|
| Initial bolus | 10-20 mg | Over 2 minutes |
| Repeat | 20-80 mg | Every 10 min |
| Max total | 300 mg | -- |
IV Infusion
Mix: 200 mg in 200 mL (1 mg/mL). Rate: 0.5-2 mg/min
| Rate (mg/min) | mL/hr |
|---|---|
| 0.5 | 30 |
| 1.0 | 60 |
| 1.5 | 90 |
| 2.0 | 120 |
Nicardipine
Mix: 25 mg in 250 mL NS (0.1 mg/mL)
| Rate (mg/hr) | mL/hr |
|---|---|
| 5 (start) | 50 |
| 7.5 | 75 |
| 10 | 100 |
| 12.5 | 125 |
| 15 (max) | 150 |
Nitroglycerine
Mix: 50 mg in 250 mL D5W (200 mcg/mL)
| Dose (mcg/min) | mL/hr |
|---|---|
| 5 (start) | 1.5 |
| 10 | 3 |
| 20 | 6 |
| 40 | 12 |
| 60 | 18 |
| 80 | 24 |
| 100 | 30 |
| 200 (max) | 60 |
Norepinephrine IV Drip
Stock: 4 mg/4 mL
| Dose (mcg/kg/min) | mL/hr |
|---|
Ketamine for Analgesia
Morphine IV
PCA Settings
| Parameter | Setting |
|---|---|
| Demand dose | 1-2 mg |
| Lockout interval | 6-10 min |
| Basal rate (optional) | 0-1 mg/hr |
| 4-hour limit | 10-30 mg |
Lidocaine 2% IV for Analgesia
Stock: Lidocaine 2% (20 mg/mL). Mix: 2 g in 250 mL NS (8 mg/mL)
Local Anesthetic Concentration Calculator
Common Concentrations
| Drug | % | mg/mL | Use |
|---|---|---|---|
| Bupivacaine | 0.0625% | 0.625 | Epidural infusion |
| Bupivacaine | 0.125% | 1.25 | Epidural infusion |
| Bupivacaine | 0.25% | 2.5 | Nerve block / Epidural |
| Bupivacaine | 0.5% | 5 | Nerve block / Spinal |
| Lidocaine | 1% | 10 | Infiltration |
| Lidocaine | 2% | 20 | Nerve block |
| Ropivacaine | 0.2% | 2 | Epidural infusion |
| Ropivacaine | 0.5% | 5 | Nerve block |
Bupivacaine Epidural
| Parameter | Value |
|---|---|
| Concentration | 0.0625% - 0.25% |
| Rate | 6-14 mL/hr |
| Max dose (plain) | 140 mg (2 mg/kg) |
| Max dose (with epi) | 210 mg (3 mg/kg) |
| Onset | 15-20 min |
| Duration | 2-4 hours |
Morphine Epidural
| Parameter | Value |
|---|---|
| Dose | 2-5 mg preservative-free |
| Onset | 30-60 minutes |
| Duration | 12-24 hours |
| Concentration | 0.5 mg/mL or 1 mg/mL (Duramorph) |
Ropivacaine Epidural
| Parameter | Value |
|---|---|
| Concentration | 0.1% - 0.2% |
| Rate | 6-14 mL/hr |
| Max dose | 210 mg (3 mg/kg) |
| Onset | 15-20 min |
| Duration | 2-6 hours |
Atracurium
Stock: 10 mg/mL
| Parameter | Dose | Calculated |
|---|---|---|
| Intubating dose | 0.4-0.5 mg/kg | 28-35 mg |
| Maintenance bolus | 0.08-0.1 mg/kg q15-25min | 5.6-7 mg |
| Infusion | 5-9 mcg/kg/min | 350-630 mcg/min |
Drip Regulation
| Dose (mcg/kg/min) | mL/hr |
|---|
Cisatracurium
| Parameter | Dose | Calculated |
|---|---|---|
| Intubating dose | 0.15-0.2 mg/kg | 10.5-14 mg |
| Maintenance bolus | 0.03 mg/kg q20min | 2.1 mg |
| Infusion | 1-3 mcg/kg/min | 70-210 mcg/min |
Drip Regulation
| Dose (mcg/kg/min) | mL/hr |
|---|
Rocuronium
| Parameter | Dose | Calculated |
|---|---|---|
| Intubating dose | 0.6 mg/kg | 42 mg |
| RSI dose | 1.2 mg/kg | 84 mg |
| Maintenance | 0.1-0.2 mg/kg | 7-14 mg |
| Infusion | 10-12 mcg/kg/min | 700-840 mcg/min |
Drip Regulation
| Dose (mcg/kg/min) | mL/hr |
|---|
Sugammadex
| Indication | Dose | Calculated |
|---|---|---|
| Routine reversal (T2 reappearance) | 2 mg/kg | 140 mg |
| Deep block (PTC 1-2) | 4 mg/kg | 280 mg |
| Immediate reversal (RSI rescue) | 16 mg/kg | 1120 mg |
Pediatrics
Airway
Induction & Drugs
| Drug | Dose/kg | Calculated |
|---|
Fluids
Emergency Drugs
Weight Estimation Reference
| Age | Est. Weight | ETT | ETT Depth |
|---|---|---|---|
| Premature | 1-2.5 kg | 2.5-3.0 | 7-9 cm |
| Term neonate | 3-4 kg | 3.0-3.5 | 9-10.5 cm |
| 3 months | 5-6 kg | 3.5 | 10.5 cm |
| 6 months | 7-8 kg | 3.5-4.0 | 10.5-12 cm |
| 1 year | 9-10 kg | 4.0 | 12 cm |
| 2 years | 12 kg | 4.5 | 13.5 cm |
| 4 years | 16 kg | 5.0 | 15 cm |
| 6 years | 20 kg | 5.5 | 16.5 cm |
| 8 years | 24 kg | 6.0 | 18 cm |
| 10 years | 28 kg | 6.5 | 19.5 cm |
| 12 years | 36 kg | 7.0 | 21 cm |
Body Mass Index Calculator
| Category | BMI Range |
|---|---|
| Underweight | < 18.5 |
| Normal weight | 18.5 - 24.9 |
| Overweight | 25 - 29.9 |
| Obese Class I | 30 - 34.9 |
| Obese Class II | 35 - 39.9 |
| Obese Class III | ≥ 40 |
ABG Interpreter
Normal Values Reference
| Parameter | Normal |
|---|---|
| pH | 7.35 - 7.45 |
| PaCO2 | 35 - 45 mmHg |
| HCO3 | 22 - 26 mEq/L |
| PaO2 | 80 - 100 mmHg |
| Base Excess | -2 to +2 |
| Anion Gap | 8 - 12 |
Supraglottic Airway (SGA) Sizes
iGel Sizes
| Size | Color | Patient Weight |
|---|---|---|
| 1 | Pink | 2 - 5 kg |
| 1.5 | Blue | 5 - 12 kg |
| 2 | Green | 10 - 25 kg |
| 2.5 | Orange | 25 - 35 kg |
| 3 | Yellow | 30 - 60 kg |
| 4 | Red | 50 - 90 kg |
| 5 | Purple | 90+ kg |
LMA Sizes
| Size | Patient Weight | Max Cuff Volume (mL) |
|---|---|---|
| 1 | < 5 kg | 4 |
| 1.5 | 5 - 10 kg | 7 |
| 2 | 10 - 20 kg | 10 |
| 2.5 | 20 - 30 kg | 14 |
| 3 | 30 - 50 kg | 20 |
| 4 | 50 - 70 kg | 30 |
| 5 | 70 - 100 kg | 40 |
Bicarbonate Replacement
NaHCO3 8.4% = 1 mEq/mL
Expected Body Weight
Ideal Body Weight
Single Shot Nerve Blocks (Ultrasound-Guided)
| Block | Volume | Dose (mg) | Duration |
|---|
Ultrasound Guidance by Block
Interscalene Block
Probe: Linear, transverse on lateral neck at C6 level (cricoid)
Target: C5-C7 nerve roots between anterior and middle scalene muscles
Needle: In-plane, lateral to medial
Volume: 15-20 mL
Watch for: Phrenic nerve palsy, vertebral artery, epidural/intrathecal spread
Supraclavicular Block
Probe: Linear, coronal oblique in supraclavicular fossa
Target: Brachial plexus (divisions) — "cluster of grapes" lateral and posterior to subclavian artery, above 1st rib
Needle: In-plane, lateral to medial
Volume: 20-30 mL
Watch for: Pneumothorax (pleura), subclavian artery
Infraclavicular Block
Probe: Linear or curvilinear, parasagittal below clavicle midpoint
Target: Lateral, posterior, and medial cords around axillary artery (posterior cord at 6 o'clock)
Needle: In-plane, cephalad to caudad. Target posterior to axillary artery
Volume: 20-30 mL | Duration: 12-24 hr
Watch for: Pneumothorax, axillary vessels
Axillary Block
Probe: Linear, transverse on proximal medial arm (axilla), arm abducted 90°
Target: Median (superficial to artery), ulnar (medial), radial (posterior to artery), musculocutaneous (within coracobrachialis)
Needle: In-plane. Deposit LA around each nerve
Volume: 20-30 mL (5-8 mL per nerve) | Duration: 10-16 hr
Watch for: Axillary artery puncture, intravascular injection
Femoral Nerve Block
Probe: Linear, transverse at inguinal crease
Target: Femoral nerve — lateral to femoral artery, deep to fascia iliaca, on iliopsoas
Needle: In-plane, lateral to medial
Volume: 15-20 mL
Remember: N-A-V-L (Nerve, Artery, Vein, Lymphatics) lateral to medial
Watch for: Femoral artery/vein puncture, quadriceps weakness (fall risk)
Adductor Canal Block
Probe: Linear, transverse at mid-thigh (deep to sartorius muscle)
Target: Saphenous nerve adjacent to superficial femoral artery, deep to sartorius, between vastus medialis and adductor longus
Needle: In-plane, lateral to medial through sartorius
Volume: 15-20 mL | Duration: 12-18 hr
Advantage: Motor-sparing (preserves quadriceps strength) vs femoral block
TAP Block (Transversus Abdominis Plane)
Probe: Linear, transverse between costal margin and iliac crest at mid-axillary line
Target: Fascial plane between internal oblique and transversus abdominis muscles
Needle: In-plane, anterior to posterior. Hydrodissection of plane
Volume: 20 mL per side | Duration: 12-24 hr
Coverage: T10-L1 dermatomes (abdominal wall)
Popliteal Sciatic Block
Probe: Linear or curvilinear, transverse in popliteal fossa (patient prone or lateral)
Target: Sciatic nerve before bifurcation (~5-8 cm above popliteal crease), or tibial + common peroneal individually
Needle: In-plane, lateral to medial. Inject where nerves are still in common sheath
Volume: 20-30 mL | Duration: 18-24 hr
Watch for: Popliteal artery/vein (anterior to nerve), intraneural injection
Continuous Nerve Block Infusions
| Block | Drug | Rate | Bolus |
|---|---|---|---|
| Interscalene | Ropivacaine 0.2% | 5-8 mL/hr | 5 mL q60min PRN |
| Supraclavicular | Ropivacaine 0.2% | 5-8 mL/hr | 5 mL q60min PRN |
| Infraclavicular | Ropivacaine 0.2% | 5-8 mL/hr | 5 mL q60min PRN |
| Femoral | Ropivacaine 0.2% | 5-8 mL/hr | 5 mL q60min PRN |
| Adductor Canal | Ropivacaine 0.2% | 6-8 mL/hr | 5 mL q60min PRN |
| Popliteal Sciatic | Ropivacaine 0.2% | 5-8 mL/hr | 5 mL q60min PRN |
Arterial Line Insertion
Indications
- Continuous BP monitoring
- Frequent ABG sampling
- Hemodynamically unstable patients
- Major surgical procedures
Technique (Radial Artery - Modified Seldinger)
- Position: Wrist dorsiflexion 30-45°, tape hand to arm board
- Prep and drape. Infiltrate with 1% lidocaine
- Palpate radial pulse (or use ultrasound)
- Puncture at 30-45° angle. Advance until flash of blood
- Lower angle, thread guidewire. Remove needle
- Thread catheter (20G) over wire. Remove wire
- Connect to transducer, confirm waveform, secure
Basic Echocardiography
Standard Views
| View | Probe Position | Key Assessments |
|---|---|---|
| Parasternal Long Axis | Left sternal border, 3-4th ICS | LV size/function, MV, AV, pericardium |
| Parasternal Short Axis | Rotate 90° from PLAX | LV wall motion, RV, septal motion |
| Apical 4-Chamber | Apex, left lateral decubitus | All 4 chambers, valves, RV/LV comparison |
| Subcostal | Subxiphoid, flat angle | Pericardial effusion, IVC, global function |
| IVC View | Subcostal, rotate longitudinal | Volume status (IVC diameter/collapse) |
Internal Jugular Catheter Insertion
Technique (Ultrasound-Guided Seldinger)
- Position: Trendelenburg, head turned slightly contralateral
- Identify IJ with ultrasound (compressible, lateral to carotid)
- Prep, drape, local anesthetic
- Needle at 45° under real-time ultrasound guidance
- Aspirate venous blood (dark, non-pulsatile)
- Thread J-tip guidewire. Confirm with ultrasound
- Nick skin, dilate, thread catheter. Remove wire
- Aspirate all ports, flush. Secure and dress
- Confirm placement with chest X-ray (tip at SVC-RA junction)
Intraosseous Access
Indications
Emergency vascular access when IV access cannot be obtained within 90 seconds or after 2 failed attempts.
Sites (in order of preference)
| Site | Landmark |
|---|---|
| Proximal tibia | 1-2 cm below tibial tuberosity, medial flat surface |
| Distal tibia | 1-2 cm above medial malleolus |
| Proximal humerus | Greater tubercle (adults preferred with EZ-IO) |
| Distal femur | 2 cm above patella, midline (pediatric) |
Insertion Site Diagrams
Medial flat surface
Flat medial surface
Adults preferred (EZ-IO)
Pediatric patients
Technique
- Identify landmark. Clean and prep the site.
- Stabilize the limb. Do NOT place hand behind insertion site.
- Insert IO needle perpendicular (90°) to bone with gentle rotating/drilling motion.
- Feel a "pop" or loss of resistance when entering the marrow cavity.
- Remove stylet. Aspirate marrow (not always possible).
- Flush with 5-10 mL NS. Observe for extravasation.
- Connect IV tubing. Use pressure bag for fluids.
PICC Line Insertion
Peripherally Inserted Central Catheter
- Measure: insertion site to right sternal border, down to 3rd ICS
- Select vein with ultrasound (basilic preferred > brachial > cephalic)
- Prep, drape, local anesthetic
- Access vein under ultrasound, advance guidewire
- Introduce peel-away sheath, advance catheter to measured length
- Confirm tip position: chest X-ray (lower SVC / cavo-atrial junction)
Point of Care Ultrasound (POCUS)
FAST Exam (Focused Assessment with Sonography for Trauma)
| View | Location | Looking For |
|---|---|---|
| RUQ (Morrison's pouch) | Right mid-axillary, 8-11th rib | Free fluid between liver/kidney |
| LUQ (Splenorenal) | Left posterior axillary, 6-9th rib | Free fluid around spleen |
| Suprapubic | Midline above symphysis | Free fluid in pelvis |
| Subxiphoid | Below xiphoid process | Pericardial effusion |
Lung Ultrasound
| Finding | Interpretation |
|---|---|
| Lung sliding + A-lines | Normal aerated lung |
| B-lines (>3 per zone) | Pulmonary edema / interstitial fluid |
| Absent lung sliding | Pneumothorax (confirm with M-mode) |
| Lung point | Confirms pneumothorax border |
O2% (FiO2) Calculator
Contact
For suggestions, improvements, or bug reports:
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This project is maintained for anesthesiology resident for educational purposes. Feedback is welcome to improve accuracy and usability.
Disclaimer
This tool is for educational purposes only.
The information provided is not a substitute for professional clinical judgment. Drug doses and protocols should always be verified independently before clinical use. The authors assume no liability for any errors or outcomes related to the use of this tool.
Always consult current institutional guidelines, pharmacopeias, and package inserts for the most up-to-date dosing information.